Objective  To investigate the prediction of mortality in hemodialysis patients with diabetic nephropathy by albumin/globulin ratio (AGR).Methods  A total of 90 cases diabetic nephropathy patients in hemodialysis who were selected in our hospital and followed up regularly from January 1,2010 to January 1,2018 and whose condition was stable. Baseline data were collected, including general data, laboratory tests, comorbidities, medication, etc. Patients were divided into AGR≥1.2 group(66 cases) and AGR<1.2 group(24 cases) according to blood AGR value, and the baseline data of the two groups were compared.Results  There were statistically significant differences in cardiovascular disease ratio, fasting blood glucose, glycated red egg, albumin, total protein, globulin ratio, hemoglobin and serum creatinine between the two groups (all P<0.05). There were 8 (17.8%)and 6 (37.5%) deaths in AGR≥1.2 group and the AGR<1.2 group, respectively. Univariate and multivariate Cox regression analysis showed that low AGR was an independent predictor of death in hemodialysis patients with diabetic nephropathy.Conclusions  The AGR can predict mortality in diabetic nephropathy hemodialysis patients.