Objectives To present the surgical methods and the clinical efficacy of the laparoscopic radical cystectomy (LRC) with orthotopic ileal neobladder. Methods The clinical data of 30 cases of patients underwent laparoscopic radical cystectomy (LRC) with orthotopic ileal neobladder were analyed retrospectively and summarized between May, 2007 and Oct, 2011。Result All the operations were successfully completed without conversion to open surgery. TheOperation time is 180 ~ 360min with a mean of 240min.The intraoperatve bleeding is 150~450 ml with a mean of 220 ml.The bowel recovery time was 4-8 days.The followed up time were from 6 to 60 mouths, median follow-up time was 26 mouths. 30 cases achieved urine control function with satisfaction. the mean value of neobladder maximum capacity were 398 ml and the night-time urination were 1~3 times. 1 case occurred nocturnal enuresis and 2 cases occurred urinary leak. Cystoscopy were not found the cancer recurrence in urethra.2 cases died of metastasis of the primary disease and the blood biochemical examination of other patients were essentially normal with following up for 6 months, B-ultrasonic examination were not found the dilation or seeper in bilateral upper urinary tract.Conclusions laparoscopic radical cystectomy (LRC) with orthotopic.