Objective: To explore the efficacy and affecting factors of muscle-invasive bladder cancer (MIBC) patients treated by partial cystectomy(PC) combined with bladder perfusion chemotherapy.Methods:To retrospectively collect the clinical data of 55 cases MIBC patients from hospital secondly uropoiesis surgical department,and all patients were treated by PC combined with bladder perfusion chemotherapy,observed with the 5 years cancer specific survival ，overall survival and relapse rate,selected the potiential influence factors of 5 years before cancer specific survival using the single factor analysis,then used the logistic regression analysis.Results: The follow-up time was 10 to 60 months, the median follow-up time was 44 months,the 5 years cancer specific survival, overall survival and relapse rate were respectively 72.73%（40 cases）、61.82%（34cases）and 30.91%（17cases）,χ² test showed that petients whose age ≥60, T₃ stage, had a history of bladder tumor, multiple tumor, tumor ≥5cm ,their 5 years cancer specific survival significantly reduced, and combined with ureteral reimplantation (UR) treatment the 5 years cancer specific survival  significantly rised,the difference had statistical significance (P<0.05); Multiariable Logistic regression analysis showed that tumor ≥5 cm, multiple tumor, muscular T₃ stage were risk factors for invasive bladder cancer prognosis, they could reduce cancer specific survival rate, and combined therapy with UR was its protection factor, it could increase cancer specific survival.Conclusion: PC combined with bladder perfusion chemotherapy is a feasible retention bladder surgery on treating MIBC,combined with UR treatment can improve prognosis, and the 5 years cancer specific survival in patients with tumor≧5 cm, multiple and T₃ stage are decreased obviously,we will not recommended preserve bladder surgery.