Objective To investigate the expressions of SF-1 in adrenal adrenal cortical neoplasm as well as to discuss its clinical significance. Methods 52 adrenal cortical neoplasm samples acquired from patients were examined by immunohistochemistry for the expressions of SF-1．The patients were stratified into two groups according to the pathological characteristic.we used a matched pairs approach by selecting for each patient from the benign group(n=25）and  one corresponding patient from the ACC group（n=27).Results We showed that the marjority of ACC patients expressed SF-1(20/27,74.07%) .Contrarily，the expression of SF-1 in the benign group was low(10/25,40.00%).There was significant difference (P<0.05) between the two groups.Malignant cases showed higher MVD compared to benign tumors（69.22 22.56 vs27.76 22.49，P<0.05 ）There was positive correlation between SF-1 and MVD（P<0.01）.The high expression of SF-1 might lead to a poor prognosis.Conclusion  The high expression of VEGF in ACC may be a event that make contribution to tumor angiogenesis，which represents a selective target for antiangiogenic therapies.