Objective: To evaluate the efficacy and safety of percutaneous nephrolithotomy (PCNL) in secondary surgery of recurrent  kidney  stones.Method: Retrospective analysis of 24 cases of percutaneous nephrolithotomy  in treatment of recurrent kidney stones in our hospital from 2010 June to 2013 July.Result: 24 patients underwent PCNL surgery, and postoperative KUB showed 21 cases of stone cleared, of which stone clearance rate was 87.5%; 3 patients had residual calculi.One patient who failed to take calculus underwent extracorporeal shock wave lithotripsy after surgery. A second PCNL was applied to one case with postoperative extracorporeal shock wave lithotripsy. Operation time was from 40 to 110 mins, average 80 mins. No serious complications occurred after operation.Conclusion: Percutaneous nephrolithotomy is a safe and effective method in secondary surgery of recurrent kidney stones.