Objective : To study the treatment effect of bladder resection plus chemotherapy to the muscular layer of pelvic lymph node negative invasive bladder cance , to report the effectiveness of the treatment method and to investigate the prognostic factors. Methods : To selected from February 2008 to our hospital oncology has implemented a muscle invasive bladder cancer partial cystectomy plus adjuvant chemotherapy and clinically relevant information on persons , 50 cases were included as a treatment group . To select the same period, while the muscle to accept radical cystectomy for invasive bladder cancer treated 50 cases of people as a control group , and carefully collect clinical data . The treatment group and the control group were analyzed efficiently . Risk factors for analyzing the impact of pelvic lymph node -negative muscle invasive bladder cancer , the authors further analyzed by logistic regression . Results: The results showed that the treatment group was the Institute 's effective rate of 87.50% , the effective rate was 83.33 % in the control group , two groups that the treatment group and the control group does not exist in terms of an efficient statistical difference (P> 0.05) but by staging comparison, we obtained highly selective group of patients was significantly higher efficiency and statistically significant (P <0.05). logistic regression analysis was measured pathological grade (P = 0.001, P <0.05) and pathological stage (P = 0.002, P <0.05) were independent risk factors for the pelvic lymph node -negative muscle invasive bladder cancer . Conclusion: In this study, partial cystectomy with adjuvant chemotherapy treatments to contrast display , partial resection of bladder surgery adjuvant chemotherapy compared with radical cystectomy treatment of muscle invasive bladder cancer in all pathological grading and no advantage , but the use of the highly selective partial bladder surgery in patients with adjuvant chemotherapy treatments more effective. Pathological grading and staging of pelvic lymph node -negative muscle invasive bladder cancer were independent risk factors should receive adequate attention , thereby improving prognosis of pelvic lymph node -negative muscle invasive bladder cancer.