Abstract：Objective To investigate the diagnostic value of computed tomography (CT) combined with serum programmed cell death factor 4 (PDCD4) and Ras-related C3 botulinum substrate 1 (Rac1) in bladder cancer and its lymph node metastasis.Methods From January 2018 to December 2021, 115 bladder cancer patients who came to our hospital for surgical treatment were taken as the observation group, and 100 patients with benign diseases of the urinary system were regarded as the control group. The expression levels of PDCD4 and Rac1 mRNA in serum were detected by real-time quantitative PCR (qRT-PCR). Receiver operating characteristic (ROC) curve was applied to evaluate the diagnostic value of serum PDCD4 and Rac1 in bladder cancer and its lymph node metastasis. The diagnostic efficacy of CT scan combined with serum PDCD4 and Rac1 levels in bladder cancer and its lymph node metastasis was analyzed.Results The accuracy rate of CT combined with PDCD4 and Rac1 detection in the diagnosis of bladder cancer was 93.48%, the sensitivity was 93.04%, and the specificity was 94.00%, which was higher than the accuracy/specificity of CT detection or serum PDCD4 combined Rac1; the accuracy rate of CT combined with PDCD4 and Rac1 detection in diagnosing lymph node metastasis of bladder cancer was 95.65%, the sensitivity was 89.65%, and the specificity was 97.67%, which was higher than CT or PDCD4 and Rac1 combined detection.Conclusions Serum PDCD4 and Rac1 levels combined with CT scan can improve the accuracy and specificity of bladder cancer and lymph node metastasis, and have high diagnostic value.
