Abstract：Objective To investigate the effects of transurethral resection of bladder tumor (TURBT) and transurethral green-light laser en bloc resection (GL-EBR) on the recurrence and progression of non-muscular invasive bladder cancer (NMIBC).Methods The clinical data of 138 patients with NMIBC treated in our hospital from January 2018 to July 2020 were retrospectively analyzed, including 77 patients who underwent TURBT surgery (control group) and 61 patients who underwent GL-EBR surgery (observation group). The general data, intraoperative indicators, postoperative recurrence rate and postoperative complications were compared between the two groups. Meanwhile, according to the pathological results, the tumor grade was further divided into high grade TURBT group (group A, 17 cases), high grade GL-EBR group (group B, 21 cases), low grade TURBT group (group C, 60 cases) and low grade GL-EBR group (group D, 40 cases). The intraoperative indexes, postoperative recurrence rate and postoperative complication rate were compared among different tumor grade subgroups.Results The comparison of general data between the two groups showed no statistical significance (P>0.05), and the comparison of operation time and bladder perforation between the observation group and the control group showed no statistical significance (all P>0.05). The intraoperative blood loss and obturator nerve reflex in the observation group were less than that in the control group, the postoperative recurrence rate was lower than that in the control group. The differences were statistically significant (all P<0.05). There was no significant difference in postoperative complications between the observation group and the control group (P>0.05). In the subgroup analysis of different tumor grades, the intraoperative blood loss in group B was significantly less than that in group A (P<0.05), and the postoperative recurrence rate in group B was significantly lower than that in group A, with statistical significance (P<0.05). There were no significant differences in intraoperative blood loss, operation time, postoperative complications and postoperative recurrence rate between group C and group D (all P>0.05).Conclusions GL-EBR is safe and effective in the treatment of NMIBC, with a small amount of intraoperative blood loss, and can reduce the postoperative recurrence rate, especially for these with higher tumor grade.
