Evaluation on the clinical efficacy and safety of ultra-micro channel percutaneous nephrolithotomy and micro channel percutaneous nephrolithotomy in the treatment of renal calculi: a Meta-analysis
Abstract：Objective To evaluate the efficacy and safety of ultramicro-channel percutaneous nephrolithotripsy and micro-channel percutaneous nephrolithotripsy (mPCNL) in the treatment of renal stones.Methods The Embase, Pubmed, CNKI, China Biomedical Literature Database, Wanfang, VIP, Cochrane Library and European and American clinical trial databases were searchd from the database establishment to October 7, 2021. The procedures included mPCNL (control group) and ultramicro-channel percutaneous nephrolithotripsis [experimental group, ultra-mini PCNL（UMP） and super-mini PCNL（SMP）]. The main outcome index was stone clearance, while the secondary indexes were length of hospital stay, operation time, postoperative fever, postoperative pain, and postoperative retreatment rate.Results A total of 6 articles with 474 patients were included after excluding inconsistent studies. The results of Meta-analysis showed that there were no significant differences in stone clearance rate, postoperative retreatment rate and operation time between the two groups (all P>0.05). In the experimental group, postoperative fever (OR=0.33, 95%CI: 0.14～0.75, P=0.009), postoperative pain (OR=0.16, 95%CI: 0.07～0.40, P<0.001) and length of hospital stay (MD=-2.53, 95%CI: -4.62～-0.44, P=0.02) were better than the control group.Conclusions Ultramicro-channel percutaneous nephrolithotripsy is comparable to mPCNL in the treatment of kidney stones, but mPCNL can significantly reduce postoperative fever, pain and length of hospital stay.
