Abstract：Objective To investigate the effect of extraperitoneal laparoscopic radical prostatectomy (ELRP) and open surgery in the treatment of prostate cancer, and the differential expression of prostate specific membrane antigen (PSMA) and free prostate specific antigen (FPSAR) in serum.Methods The clinical data of 62 patients with prostate cancer admitted to our hospital from January 2016 to January 2021 were retrospectively analyzed. According to different surgical methods, they were divided into study group (36 cases underwent ELRP) and control group (26 cases underwent traditional open surgery). The perioperative conditions of the two groups were compared, including operation time, intraoperative blood loss, hospital stay, postoperative ventilation time, and catheter removal time. The incidence of postoperative complications was compared between the two groups. International Prostate Cancer Quality of Life Score was used to evaluate the quality of life of the two groups. The incidence of urinary incontinence 1 year after operation was recorded in the two groups. The levels of PSMA were detected by enzyme-linked immunosorbent assay (ELISA). The levels of total prostate specific antigen (tPSA) and free prostate specific antigen (fPSA) were determined by chemiluminescence analysis. FPSAR (fPSA/tPSA) was calculated.Results The operation time, intraoperative blood loss, hospital stay, postoperative ventilation time and catheter removal time in the study group were shorter than those in the control group (all P<0.001). The incidence of postoperative complications in the study group was 11.11% (4/36) lower than that in the control group 34.62 % (9/26) (P<0.05); The quality of life scores of the study group at 1 month and 6 months after operation were higher than those of the control group (P<0.05), and the quality of life scores of the two groups at 1 month and 6 months after operation were higher than those before operation (P<0.05). The incidence of urinary incontinence in the study group was 2.78% (1/36), which was lower than 11.54% (3/26) in the control group (P<0.05). The serum PSMA and FPSAR levels of the two groups at 1 week after operation were lower than those before operation, and the serum FPSAR levels were higher than those before operation (all P<0.05), but there was no significant difference in the serum PSMA and FPSAR levels between the two groups at 1 week after operation (all P>0.05).Conclusions Compared with open surgery, ELRP can improve the perioperative situation, reduce the incidence of postoperative complications and urinary incontinence, improve the quality of life of patients, and affect the serum PSMA and FPSAR levels of patients after surgery.
