Objective To investigate the clinical effects of programmed thulium laser transurethral enucleation of the prostate (ThuLEP).Methods Clinical dates of 79 patients with benign prostatic hypertrophy undergoing ThuLEP during January 2018 to August 2019 were retrospectively analyzed, among whom, 41 received conventional ThuLEP (control group) and 38 received programmed ThuLEP(observation group).The general preoperative data, intraoperative and postoperative recovery indicators of the two groups were compared. Results All 79 patients successfully underwent the ThuLEP. Three months after the operation, IPSS, QOL scores and Qmax were improved compared with those before the operation (P<0.05). The observation group had obvious advantages over the control group in the aspects of surgical enucleation time, hemoglobin change, bladder irrigation time, indwelling catheter time and incidence of postoperative complications(P<0.05). The IPSS scores and Qmax values in observation group were significantly improved than those in control group , but there was no statistical difference between the two group(P>0.05). Conclusions Programmed thulium laser transurethral enucleation of the prostate has better curative effect, shorter operation time, less bleeding rate, faster recovery time and fewer complications, which is worth popularized in clinical application.