Objective  To investigate the clinical value of low-pressure irrigation technique such as external drainage of ureteral catheter and irrigation with hand-held syringe in ureteroscopic holmium laser lithotripsy, and to analyze its feasibility,practicability and clinical effect.Methods  From February 2019 to January 2020,120 patients who underwent ureteroscopic holmium laser lithotripsy were randomly divided into two groups:low-pressure perfusion group and general perfusion group.In the low-pressure perfusion group,F4 ureteral catheter was placed below the stone through ureteroscope to form a return channel.The assistant used a 50 mL syringe and a three-way infusion tube to slowly inject water from the side hole of ureteroscope.In the general perfusion group, ureteroscopic holmium laser lithotripsy was performed with perfusion pump.The time and effect of operation and the incidence of postoperative complications were compared between the two groups.Results  There was no significant difference in operation time between the two groups(P>0.05).The technique of lowpressure perfusion could significantly reduce the incidence of stone residue(P<0.05),and with lower incidence of early complications such as postoperative pain in renal area,gross hematuria,transient renal dysfunction and systemic inflammatory response syndrome than that of the general perfusion group(P<0.05).Conclusions  The technique of low-pressure irrigation,such as external drainage of ureteral catheter and irrigation with hand-held syringe,is highly operable in ureteroscopic holmium laser lithotripsy,reduces the incidence of stone residue and complications such as systemic inflammatory response syndrome,has clinical application value.