Abstract：To investigate the expression of SAM68 and SENP-1 in prostate cancer tissues,their correlation and their clinical significance.Methods From January 2014 to January 2018,94 patients with the first stage of biopsy or surgical resection of the No.901 hospital of the people's liberation army joint service support force without relevant treatment were collected.Fifty cases of prostate cancer tissues were detected by immunohistochemistry.The expression of SAM68 and SENP-1 in 44 cases of benign prostatic hyperplasia,combined with clinical pathological data for statistical analysis.Results The results of immunohistochemistry showed that the positive expression rate of SAM68 and SENP-1 in prostate cancer tissues was significantly higher than that in normal prostate tissues(P<0.001). The expressions of SENP-1 and SAM68 were correlated with differentiation,TNM stage and bone metastasis (P<0.05).Correlation analysis showed that SENP-1 was positively correlated with SAM68 expression(r=0.463,P<0.001).Conclusions The high expression of SAM68 and SENP-1 in prostate cancer may be related to the occurrence and malignant progression of prostate cancer,and it is expected to be a potential target for the diagnosis and treatment of prostate cancer.
