Abstract：Objective To study the effects of hemodialysis on serum alkaline phosphatase(ALP),osteosclerosis protein(SOST) and bone metabolism. Methods From January 2016 to January 2019,116 hemodialysis patients admitted to our hospital were selected as the study group, and 50 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group. The levels of ALP,SOST and bone metabolic indexes including serum osteocalcin(OC),beta collagen(beta-CTX) and type I procollagen amino terminal propeptide(PINP) were measured by ELISA at admission and compared between the two groups. The patients in the observation group were treated with maintenance hemodialysis, and the levels of indicators before dialysis treatment,1,6 and 12 months after dialysis treatment were detected and compared. Pearson test was used to analyze the correlation between ALP,SOST and bone metabolism index in the observation group.Results Compared with the healthy control group,ALP,SOST,OC,beta-CTX, PINP and other indicators in the observation group before hemodialysis were lower than those in the control group, and there was significant difference between the two groups(P<0.05). The levels of ALP,SOST,OC,beta-CTX,PINP and other indicators in the observation group increased significantly with the prolongation of dialysis treatment time, and there were significant differences between the time points(P<0.05). Pearson test showed that ALP, SOST were positively correlated with bone metabolic indexes OC,beta-CTX and PINP in hemodialysis patients. Conclusions ALP, SOST and bone metabolic indexes in patients with hemodialysis are abnormally decreased. ALP, SOST and bone metabolic indexes in patients treated with continuous hemodialysis are improved,and ALP and SOST are positively correlated with bone metabolic indexes OC, beta-CTX and PINP.
