Abstract：Objective To compare the efficacy and safety of high-throughput hemodialysis and hemodialysis filtration in patients with chronic renal disease uremia.Methods The Cochrane library, PubMed, EMBASE, CNKI, wanfang database and CBM database were searched by computer, and the efficacy of HFHD and HDF in uremia patients was compared using randomized controlled trials and prospective controlled trials. According to the inclusion and exclusion criteria, the system evaluator independently extracts data and evaluates quality, and USES Revman 5.3 software for Meta-analysis. Results A total of 12 studies involving 829 patients were included. Meta analysis showed that compared with HDF, HFHD had better scavenge effect on metabolic wastes such as creatinine, phosphor and beta2-microglobulin in patients with uremia due to chronic renal failure,but there was no significant difference in the recovery of serum calcium and the removal of parathyroid hormone and urea nitrogen. In terms of adverse reactions, HFHD can reduce the incidence of abnormal blood pressure. There was no significant difference in the incidence of skin itching and muscle spasm. Conclusions HFHD treatment can significantly improve the dialysis efficiency of Scr, P, β2-MG and other substances and reduce the incidence of adverse reactions such as abnormal blood pressure in patients with chronic renal uremia, but has no significant improvement in the treatment effect of Ca, BUN, PTH and other factors, and cannot reduce the occurrence of adverse reactions such as pruritus and muscle spasm. However, this conclusion still needs to be verified by large-scale, high-quality RCT.
