Objective To explore the relationship between renal function and clinical and pathological features of 165 patients with idiopathic membranous nephropathy (IMN). Methods One hundred and sixty five patients with IMN from January 2010 to December 2016 in the hospital were selected in this study. According to the baseline renal function level eGFR (estimated glomerular filtration), all patients were divided into CKD1 group, CKD2 group, and CKD3+4+5 group. The demographics characteristic, clinical biochemical examination and pathological indicators were compared. Pearon or spearman correlation was used to analyze the relationship of renal function. Risk factors for eGFR decline were analyzed by binary logistic regression.Results ①Among 165 patients with IMN, the age ranged from (45.33±15.19)years (range 14 to 84 years). The clinical manifestations were nephrotic syndrome (82 cases, 49.6% ), 76 with hypertension (46.1%), 129 with edema (78.1%). ②Compared with patients with CKD stage 1, the clinical and pathological characteristics of patients above CKD stage 2 were characterized by higher proportion of males, older age, higher incidence of hypertension and nephrotic syndrome.③Correlation analysis showed that renal function was negatively correlated with age, hypertension, 24hour urinary protein, serum uric acid levels, renal interstitial inflammatory cell infiltration, renal tubular atrophy, and renal arterial wall thickening (P<0.05).④Regression analysis showed that gender, 24hour urinary protein, hyperuricemia, renal interstitial inflammatory cell infiltration were independent risk factors for renal impairment in patients with IMN. Conclusions IMN patients with initial diagnosis of age, gender, nephrotic syndrome and hypertension are associated with decreased eGFR. However, male, hyperalbuminuria, hyperuricemia, and renal interstitial inflammatory cell infiltration are important predictors of renal function in patients with IMN.
