Objective To investigate the correlation between the expression of ERG protein and the postoperative biochemical recurrence after radical prostatectomy for clinically localized prostate cancer.Methods A total of 121 patients from March 2012 to February 2016 diagnosed clinically localized prostate cancer were recruited into the study.Parameters such as age at diagnosis,prostate-specific antigen(PSA) level at diagnosis,gleason score(GS),pathological stage,surgical margin were collected retrospectively.Results A total of 98 patients completed the final followup,35.7% of the patients were found ERG protein positive(35/98). Kaplan-meier survival analysis showed that PSA level (P=0.007), GS (P=0.024) and ERG protein expression (P<0.0001) were correlated with postoperative biochemical recurrence. PSA levels(HR=2.134,P=0.001), GS(HR=1.361,P=0.030) and ERG protein expression(HR=2.024,P=0.044) were significant in predicting biochemical recurrence after radical prostatectomy for clinically localized prostate cancer.Conclusions ERG protein expression increases the risk of postoperative biochemical recurrence for prostate cancer,independent of known clinicopathological factors.
