Objective  To introduce laparoscopy combined with percutaneous nephrolithotomy lithotomy technical points and the initial experience of the treatment of renal cysts and multiple stones. Methods  20 cases of renal cysts and multiple calculi in patients undergoing laparoscopic percutaneous nephrolithotomy lithotomy joint treatment of renal cysts and multiple stones. Stones the largest 4x3cm, minimum 1x0.5cm. First laparoscopic renal cyst unroofing.Then, according to the CTA CTU tablets preoperative surgical planning and the puncture site. In the laparoscopic monitor the downlink percutaneous nephrolithotomy establish F18 stone path stone. Results  20 patients were all successful. The stones all take the best surgical results were satisfactory. The mean operative time was 90 minutes. No bleeding, urine leakage, the calyceal neck tear and ureteral stenosis and other serious complications. The average hospital stay of five days. Conclusion  The laparoscopic combined with percutaneous nephrolithotomy lithotomy can handle the kidney multiple diseases. Processing calyceal stones or calyceal neck slender, patients with renal pelvis than laparoscopic renal pelvis stone surgery operation easy removal and light neck injury and a high stone clearance. Incision laparoscopic renal pelvis lithotomy useful complement and support.