Abstract  Objective   To analyze risk factors of recurrence in patients with large size bladder cancer（diameter≥3 cm）after transurethral resection of bladder tumor (TURBT).Methods  The analysis included 107 patients with larger size bladder cancer.All 107 cases were identified from a prospective cohort of patients with larger size bladder tumor in our hospital between January 2008 and September 2014. There were 75 males and 32 females, with median age 67.8 years(22-90 years).All patients were treated with TURBT and  urinary bladder irrigation chemotherapy followed by regular further consultation.Patients were divided into two groups according to recurrence or not . Differences in gender, age, smoking or not, body mass index（BMI）,numbers of tumors(single or multiple), tumor morphology (papillary or wide base), pathological stage and grade, and the urinary bladder irrigation chemotherapy were compared between the two groups. Independent risk factors were explored by univariate and multivariate logistic regression factor analysis. Results   Recurrence was observed in 75 patients, with the rate 701%.There was no significant differences in gender, age, smoking or not, pathological stage and grade, intravesical chemotherapy or not between the two groups. Number of tumors(95%CI:1.32-9.39,P=0.012), tumor morphology(95%CI:1.50-19.84,P=0.010) were risk factors of recurrence in patients with larger size bladder cancer after TURBT. Conclusions  Multiple tumors and tumors with wide base indicate higher recurrence in patients with larger size  bladder cancer tumor after TURBT, they are independent risk factors for these patients.