Objective To evaluate the value of transrectal ultrasound guided prostate biopsy in the diagnosis of prostate cancer.Methods A total of 62 patients with suspected prostate cancer in our hospital from January 2013 to December 2016 were selected, and all patients were examined by transrectal ultrasound guided transrectal prostate biopsy. Positive detection of different puncture methods was analysed. Results Biopsy results were 25 cases of prostate cancer (40.32%).Of the 62 patients, 34 patients underwent 10 needle puncture, 28 patients underwent 12+1 needle puncture,the positive rate of the two kinds of puncture was 35.29% and 46.43%,respectively. The difference was not statistically significant (P>0.05). Positive detection rate of 10 needle puncture in patients with prostate volume ≥90 mL was 33.33%（5/15）, which significantly lower than the 12+1 needle puncture 87.50%(7/8), the difference was statistically significant (P<0.05).There was no statistically significantly difference in different age, prostate specific antigen (PSA) and rectal examination the positive detection rate between 10 needle puncture and 12+1 needle puncture (P>0.05).There was no statistically significantly difference in hematuria, bloody stool, pain，urinary retention and infectionratio between 10 needle puncture and 12+1 needle puncture after the puncture (P>0.05). Conclusions According to the specific circumstances of patients, the puncture method is selected, when patients with prostate volume more than 90 mL, we should adopt 12+1 needle puncture for diagnosis of prostate cancer, and when the < 90 mL, 10 needle puncture is a suitable method.
