Objective To investigate the association between metabolic syndrome and pathological features in radical prostatectomy.Methods All the clinical data of radical prostatectomy in our hospital from January 2009 to July 2016 were collected retrospectively.All patients were divided into metabolic syndrome group and not metabolic syndrome group. Results Of 499 patients，93（18.6%）patiens had metabolic syndrome. Compared with no metabolic syndrome group, the patients with metabolic syndrome suffered a 2.2 -fold risk（OR=2.222, 95% CI: 1.349～3.661,P=0.0002) of extraprostatic cancer and 3-fold risk (OR=3.061, 95% CI:1.313～7.137, P=0.010) of Gleason score≥8. Patients with obesity suffered 2-fold risk(OR=2.000, 95% CI:1.279～3.128,P=0.002 )of extraprostatic cancer and 2.4-fold risk(OR=2.436, 95% CI: 1.068～5.555,P=0.034) of high-risk Gleason score disease, meanwhile high blood pressure, hyperlipidaemia and hyperglycemia were not associated with more adverse prostate cancer. The risk of extraprostatic cancer increased 94%（OR=1.941, 95% CI:1.093～3.449,P=0.024）when patients had three or more components, who would suffer 4.3-fold risk(OR=4.316, 95% CI:1.530～12.174,P=0.006) of Gleason score ≥8.Conclusions Metabolic syndrome is significantly associated with extraprostatic cancer and Gleason score≥8. Obesity can predict extraprostatic cancer and Gleason score≥8.In addition, only three or more components coexisting in one patient will increase the risk of extraprostatic cancer and Gleason score≥8.
