Objective To evaluate the clinical efficacy and side effects of valsartan combined with atorvastatin on patients with diabetic nephropathy. Methods 87 diabetic nephropathy patients admitted to our hospital were recruited and divided into control group(n=45) and treatment group(n=42) by randomized random number tablea. Patients in control group were given valsartan 80mg/d. Patients in the treatment group were give valsartan 80mg/d plus atorvastatin 20mg/d. The serum Scr, MDA,CRP,UAER and GRF was compared between the two groups after 4-month treatment. Results 81 subjects completed the trial and follow-up. The serum Scr, MDA,CRP and UAER were improve in both control and treatment groups(P＜0.05). No statistical difference of side effect between the two goups was observed(P＜0.05). Significant positive correlation between CRP decrease and UAER decrease was found after treatment(rspearson=0.61, P<0.05). Conclusion More clinical efficacy was found in the valsartan combined with atorvastatin regimen group compared to control group, without increase the side effects.